Research Appraisal Assignment Guidelines
1. Read the short “Case of Mrs. Billingsly” provided below.
2. Read the five research articles listed below the case. Links to PDF copies available below
3. Appraise each of the studies using the JHNEBP Appendix E template (Research Evidence Appraisal Tool). A copy of this document is accessible below
4. Complete the “Answer Table” below. Respond to each of the concerns mentioned by Mrs. Billingsly in the scenario. Your answers should be concise and all concerns mentioned by Mrs. Billingsly should be addressed.
5. Once you have completed the table, submit a copy of this document in Canvas using the dedicated submission link for this assignment.
6. This is an individual assignment. Students should work independently and only discuss the assignment with the course instructor.
7. Rubric EBP project rubric (2).docx
8. Appendix E 2017_Appendix E_Research Appraisal Tool (2).docx
Case of Mrs. Billingsly
Mrs. Billings is calling the office to ask about whether alternating acetaminophen and ibuprophen for fever in her 6-year-old who was just diagnosed with Influenza She has only ever used acetaminophen but her sister-in-law insists alternating the two is better. She specifically concerned about the safety of combining the two and whether alternating the two medications do a better job of keeping the temp down than one alone. He currently has a temp of 101.7 using an ear thermometer. What advice will you give Mrs. Billingsly? (Your advice answer her questions and give the rationale including a citation) What advise will you give Mrs. Billingsly based on your appraisal of the five articles? Organize your response using the following table. Add or delete rows as necessary. Be sure to address each of the concerns mentioned by Mrs. Billingsly (in the scenario above).
Concern (Describe) Your Advice to Mrs. Billingsly Rationale Which Article(s) Support Your Rationale/Response to Mrs. Billingsly?

Research Articles
Arpa M, (2010) Does acetaminophen in comparison to Ibuprofen effectively reduce fevers in children younger than 18 years of age. Pediatric Nursing DOI: 105083219 Link arpa.pdf
Mullins, ME., Empey, M., Jaramillo, D., Sosa, S., Human, T., Diringer, MN., Mullins, Mi.., Empey, M.., Jaramillo, D., Sosa, S., Human, T, & Diringer,M. (2011) A prospective randomized study to evaluate the antipyretic effect of the combination of acetaminophen and ibuprofen in neurological ICU patients. Neurocritical Care 3, 375-379 DOI: 10.1007/s12028-011-9533-8 mullins.pdf
Jayawardena, S. & Kellstein, D. (2017) Antipyretic Efficacy and Safety of Ibuprofen Versus Acetaminophen Suspension in Febrile Children: Results of 2 Randomized, Double-Blind, Single-Dose Studies. Clinical Pediatrics 56(12) 1120-1128. DOI: 10.1177/0009922816678818. jayawardena.pdf
Matok, I., Elizur, A., Perlman, A., Ganor, S., Levine, H., & Kozer, E. (2017) Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness. Annals of Pharmacotherapy DOI: 10.1177/1060028016678006
marok-1.pdf
Wong, T., Thomsen, A., Stang, A., Ganshorn, H., Hartling, L., Maconochie, I., & Johnson, D. (2014) Combined and alternating paracetamol and ibuprofen therapy for febrile children. Evidence-Based Child Health DOI: 10.1002/ebch.1978 wong.pdf
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