Discuss how adrenergic and muscarinic cholinergic receptor cascades can converge on specific ion channels to modulate their behavior

Basically make an essay out of the powerpoint attached

Using cardiac L-type Ca2+ channels as a focus

– Discuss the mechanisms that control and regulate protein phosphorylation and dephosphorylation at cardiac calcium channels (beta-adrenergic stimulation and L-type calcium channels) (citing experimental evidence of the calcium channel cascade which is the AKAP binding domain)

– Discuss how adrenergic and muscarinic cholinergic receptor cascades can converge on specific ion channels to modulate their behavior

– Explain the physiological relevance of such post-translational ion channel modification

Some recommended studies:
– Catterall
, W. ( Regulation of Cardiac Calcium Channels in the
Fight or Flight Response Current Molecular Pharmacology 8 ; 12 21 (experimental evidence)

– MacLeod (2016)
Recent advances in understanding cardiac contractility
in health and disease F1000Research 5 (F1000 Faculty Rev); 1770

-Shaw &
Colecraft ( L type calcium channel targeting and local
signalling in cardiac myocytes Cardiovascular Research 98 ; 177 186

– Benitah
, Alvarez & Gomez (2010) L type Ca 2+ currents in ventricular cardiomyocytes.
Journal of Molecular and Cellular Cardiology
48 ; 26 36