What is the biochemical rationale for the use of low dose aspirin in patients with coronary artery disease Why is Ibuprofen not a good substitute for aspirin in this case?

Eicosanoids (beginning on P.222)

Using information learned from chapter 15 (beginning on P.222)(link to book below) readings on Eicosanoids, give a clear biochemical response to these questions (answers should not be more than 2 pages):

a.) A 65 year old retired construction worker is referred to the dialysis clinic following a recent diagnosis of chronic kidney disease due to a prolonged use of of the NSAID Ibuprofen. Explain the biochemical basis of NSAID nephropathy?

b.) What is the biochemical rationale for the use of low dose aspirin in patients with coronary artery disease Why is Ibuprofen not a good substitute for aspirin in this case?

https://labalbaha.files.wordpress.com/2014/04/medical-biochemistry-human-metabolism-in-health-and-disease.pdf