What precautions should be taken when caring for a woman of childbearing age who is homozygous for the factor V Leiden allele?

Module 13

• Label the answer to the question number or letter.
• Indicate the question you pick. Cite at least 4 references no older than (2020) or 3 years relevant to the discussion topic/questions. APA 7. For all assignments: All assignments must be written in an academic tone. You are not to write in the first person. Instead, you need to use the third person. Large word-for-word quotes are not permitted. Direct quotes, if used, need to be only a sentence or two long. Instead, most cited material needs to be paraphrased. References should consist of scholarly journals. Web sources can be used, though they should come from credible sources such as government agencies, academics, and private agencies with a strong reputation within the community they serve. You will not be allowed to use web pages or web groups such as Wikipedia or Answers.com, as the information contained in these web pages is academically questionable. You cannot use web pages with a questionable background or academic source. Furthermore, you will not be permitted to cite encyclopedias, dictionaries, newspapers, or magazines. It is important to remember evidence-based.

Cardiovascular Assignment:
Additional resources:
General Physical Activities Defined by Level of Intensity: http://www.cdc.gov/nccdphp/dnpa/physical/pdf/PA_Intensity_table_2_1.pdf

Genetics of Heart Disease
https://www.cdc.gov/heartdisease/risk_factors.htm

1. What precautions should be taken when caring for a woman of childbearing age who is homozygous for the factor V Leiden allele?

2. Case Study: Edgar is 56 years old. His father died of a stroke at age 76. His mother had hypertension and died of a myocardial infarction at age 64. Edgar has three siblings; two have hypertension and are smokers. One had a stroke at age 54. Edgar’s uncle Pete died of a stroke at age 64. Edgar does not smoke and has normal blood pressure. He wants to know what his genetic risk is for having a stroke because he has seen a TV special on genetics and is considering having genetic testing.

a. What could you tell Edgar about the genetics of stroke?
b. Would Edgar benefit from genetic counseling?
c. Should Edgar’s children (ages 36 and 30) have genetic testing?

3. Case Study: Karen’s brother (Charlie) has a genetic cardiac disorder that puts him at high risk for sudden cardiac death. He has had one episode and is now being treated with medications and an implanted cardioverter defibrillator. This disorder is transmitted in families in an autosomal dominant pattern, and genetic testing is available. Karen and Charlie’s dad died at age 39 of a single car crash. The family always assumed that it was suicide because he had been depressed, but the family doctor suggested that he may have had a cardiac arrest, just as Charlie did. Karen drives a school bus and has not talked to her brother in 10 years. The last time they saw each other was at their father’s funeral. Charlie is asked to inform his sister of her genetic risk, but he refuses.
a. What is Karen’s risk of being affected with this disorder?
b. What ethical principles are involved in this case?
c. What would you do if you were Charlie’s health-care provider?

4. One form of polycystic kidney disease (PKD) has an autosomal dominant transmission pattern. Explain why a 60-year-old man with the disease still has about 25% kidney function remaining but his monozygotic twin daughters had such severe disease that they each had to have a kidney transplant by age 18 (assuming that all three of them had very good care and were very adherent to their medical regimens).