Telomeres mark the end of chromosomes, and they are know to be repressive for transcription. Explain how they do this, what proteins are found at telomeres and where they are located in the nuclear compartment.

1st question: NF-kB transcription activity is involved in mediating different responses including immune and inflammatory. Please describe the family of NF-kB transcription factors and how they work to regulate gene expression.  (With references)

2nd question: Telomeres mark the end of chromosomes, and they are know to be repressive for transcription. Explain how they do this, what proteins are found at telomeres and where they are located in the nuclear compartment.  (With references)