Discuss the normal anatomy and physiology of the organ system involved (cell and tissue populations involved, organs, primary functions, connections to other body systems)

This research paper is on Cardiovascular Disease. The article summary attached has to be used as one of the sources.

The Research Paper must include:
• Introduction to the disease and the organ system (history, signs, symptoms, epidemiology etc.)
• Discussion of the normal anatomy and physiology of the organ system involved (cell and tissue populations involved, organs, primary functions, connections to other body systems)
• Discussion of the changes to the anatomy and physiology as a result of the disease (pathophysiology)
• Discussion of treatment/prevention options
• 3 primary and at least 2 secondary scholarly sources