Hedgehog pathway
As the articel mentioned, Vismodegib (Erivedge) is a drug that is a hedgehog pathway inhibitor and is being used to treat adults with metastatic basal cell carcinoma (Riaz, Ke, Wang, & Kayan, 2019). In basal cell carcinoma, tumors contain mutations that are either inactivate Patched which allows for the hedgehog pathway to be turned on, or active SMO which turns on the hedgehog pathway inappropriately. This drug blocks the activation of the hedgehog pathway by binding to SMO (Wilkes, 2012). Besides cancer, what other diseases does the hedgehog pathway contribute to?
