Clarify how additional tests (from both haematology and biochemistry) are essential to distinguish the cause and elicit the correct diagnosis for the patient, and how this would impact the treatment they would need to receive.

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  1. A 75-year-old man complained to his general practitioner (GP) about his recent weight loss and bone pain. Although a non-smoker, he has had several recent chest infections and has become increasingly short of breath on exertion. Routine biochemistry tests have been carried out and reveal that he has an increase in both his total protein and globulin protein fractions. This has prompted serum protein electrophoresis (SPE) of his sample which has revealed a monoclonal band in the mid-gamma region

Based on this limited information:

  1. (a)  Carefully consider the differential diagnoses that need attention when a patient is found to have a monoclonal band in their blood plasma, and the pathological process by which they arise. (30 marks)
  2. (b)  Clarify how additional tests (from both haematology and biochemistry) are essential to distinguish the cause and elicit the correct diagnosis for the patient, and how this would impact the treatment they would need to receive. (70 marks)

Instructions to authors

As a general rule for these case study assignments, it is important to remember that credit is gained not only for a correct final diagnosis, but for an answer that contains a careful analysis and logical explanations of the sequence of laboratory tests performed and expected results.There is a word limit which requires a very succinct analysis and response; the aim of this is to judge a student’s proficiency in selecting key information and presenting arguments and analysis concisely and clearly.To allow for concise responses to be made there is no need to frame answers within a ‘traditional’ essay style structure- specific questions are usually posed and can be addressed directly in order, e.g. using the specific questions set as sub-headings or sections.Information sources should be referenced in the usual way; unnecessary references will not gain you credit, and poor/inappropriate use of references may indicate poor judgement in referencing skills. References are not included as part of the word count BUT should be presented according to the PABS referencing guide.

The word limit is 1500 WORDS per case and MUST be stated at the end of your work.

Deadline for submission for is Wednesday 20th January at 14:00pm

 

Discuss the preparation and application of cDNA libraries.

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A 300 word short, precise essay focusing on the advantages and disadvantages of the mechanism of cDNA preparation and the uses of cDNA libraries.

Describe the background and basic issue of your chosen topic.

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Genetically modified foods

Consult resources other than the course textbook and your reading assignments. Examples of resources include other textbooks, journal articles, and reputable websites. Reputable online sources include encyclopedias and university or governmental websites. Never use Wikipedia as a source for a research paper. Prepare a detailed report on the topic you choose, including the following elements:

1.Describe the background and basic issue of your chosen topic.
2.Describe the basic argument of opposing viewpoints.
3.Identify the strengths and weaknesses of both views.
4.Choose which view you agree with. (Only in the conclusion)
5.Explain why you agree with that view.

Incorporate the information you learned about your chosen topic from this course, but don’t limit your discussion to the textbook and study guide. Take advantage of external resources to provide an in-depth, comprehensive report.

Goal
This assignment is designed to help you apply what you’ve learned from your lessons by researching and writing about a controversial topic you’ve studied and to give you an opportunity to demonstrate your written communication, research, and critical thinking skills.

Writing Guidelines
Type your submission, double-spaced, in a Times New Roman font, size 12. Use a standard document format with 1-inch margins. (Do not use any fancy or cursive fonts.)
Read the assignment carefully and address the topic suggested.
Be specific. Limit your submission to the topic suggested.
Use proper APA formatting. Include in-text citations and a reference page in APA style. On this page list websites, journals, and all other references used in preparing the submission. Also include a cover page and in-text citations.

Explain the effect of increasing temperature and CO2 on growth rates of marine phytoplankton

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Discuss the results with reference to scientific literature (1500 words. Evaluate the methods used, present methodological critique (1500 words).

Describe one likely difference in their recovery, for each of BONE and SMOOTH MUSCLE

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John (25 years old) and his mother Jane (60 years old) are in a car accident.

(4 marks total)

  1. Both John and Jane break several ribs, and also suffer abdominal trauma, requiring surgery to their intestines.

Describe one likely difference in their recovery, for each of BONE and SMOOTH MUSCLE (in the intestinal wall), based on their age. (3 marks)

  1. John also suffers damage to his spinal cord during the accident. Compare the likely recovery of his SPINAL CORD compared to the SMOOTH MUSCLE of his intestinal wall, and long term consequences. (1 mark)

Which type of bone marrow is able to convert into the other, and under what circumstances?      

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Describe the functional differences between red and yellow bone marrow, and where they are generally located.

Which type of bone marrow is able to convert into the other, and under what circumstances?          

Distinguish between facilitated diffusion, and secondary active transport.

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Distinguish between facilitated diffusion, and secondary active transport. For each, provide an example of a molecule or ion that uses this mechanism to cross the cell membrane.  In your answer, explain what characteristics of the particle being transported determines which method is used, including its relative concentration on both sides of the membrane.    

Distinguish between the function of simple columnar epithelium and simple squamous epithelium.

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Distinguish between the function of simple columnar epithelium and simple squamous epithelium, providing a brief example of the function of each.

Describe one similarity and one difference between steroid and protein hormones.

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Describe one similarity and one difference between steroid and protein hormones.

What is Jezebel and Goldie’s phenotype and possible genotype(s)?

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Mark has been away on holiday, and his friends Shruti and Shokoofeh took turns looking after his dog, named Jezebel.   Jezebel is a female with yellow fur, and shortly after Mark returns from his holiday, it becomes obvious his dog is pregnant. She gives birth to three puppies, all of which have yellow fur.

Mark is very upset, and blames Shruti, because Shruti owns a male dog with yellow fur (named Goldie).   Shokoofeh owns a male dog (named Blackie), but because he has black fur, Mark doesn’t think he can be the father.

Assume that the gene for colour of fur is located on autosomal chromosomes and ‘black’ fur colour is dominant, and ‘yellow’ fur colour is recessive.  Assume there are no new mutations.  Assume the genetics of dog fur colour work the same way as human hair colour.

  1. What is Jezebel and Goldie’s phenotype and possible genotype(s)?
  1. What is Blackie’s phenotype and possible genotype(s)?
  2. What are the puppies’ phenotypes and possible genotype(s)?
  3. Based only on the fur colour of the two possible fathers, is it certain that Goldie is the father? Explain your answer.