What solvent system worked for dissolving the solid samples prior to running a TLC plate? Why would you recommend that solvent system?

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ORGANIC CHEMISTRY LABORATORY I

Separation and Purity Techniques: Thin–Layer Chromatography and Melting Point

OBJECTIVES:
1) Investigate solubility of organo–metallic compounds
2) Advise a solvent system for proper separation of organo–metallic compounds on TLC plate
3) Determine the melting point of organo–metallic compounds

Note: All background regarding TLC and melting point determination has been covered in previous activities. You are encouraged to refer to these documents for an overall review prior to completing this activity. Obtain some samples of ferrocene and its derivatives from the instructor and advise a solvent system for proper separation of these compounds on a TLC plate. Also, record melting points for these samples.

Research Proposal Preliminary Data Questionnaire – Review MEMO Grading Rubric
You are tasked to analyze ferrocene analogs and become familiar with working with a variety of these molecules. As organometallic complexes have distinct and diverse instrumental analyses resulting from the metal to organic ligand bonding, it is critical to note the difference and predict the instrumental signals for these complexes that might deviate from the original expected behavior of organic ligand in the absence of the metal. You are provided a set of analogs to analyze using organic techniques and instrumentation. An active anti–cancer ferrocene molecule will be assigned to your group and you are to predict the expected results using your information you find from studying the standard analogs.

1) From your measurements of the melting points of ferrocene, what did you note about purity? These samples have reported melting point ranges.

2) Was there a trend in the melting point with the change from the parent to the derivative compound? How does the structure of the analogs impact the melting point? Think about  IMF/Supramolecular forces.

3) What solvent system worked for dissolving the solid samples prior to running a TLC plate? Why would you recommend that solvent system?

4) Did you establish a separation of the ferrocene compounds on TLC plate? What structural modifications does your assigned compound of interest have?

5) Based on the structure of our compound and the collected preliminary data, what do you expect the melting point and the polarity of your assigned compound of interest?

What are the properties of iron?

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Organic chemistry

What are the properties of iron?

Using the chemical formulas from question 2 to write the structures step-by-step to obtain the Lewis dot structures and show how you balance the charges.

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Chapter 4 Compounds and Their Formulas

Homework #4
You must show your entire work on a separate sheet(s) of paper to get full credit.

Chapter 4

1. Draw the Lewis dot structures for the following imaginary elements

  • a. X, an element from the Group IA family
  • b. Z, an element from the Group IIA family
  • c. J, an element from the Group IVA family
  • d. K, an element from the Group VIA family

2. Use the Crossover Method to determine the following ionic chemical formula.

  • a. iron(III) sulfide
  • b. calcium hydride
  • c. magnesium nitride
  • d. aluminum fluoride

3. Using the chemical formulas from question 2 to write the structures step–by–step to obtain the Lewis dot structures and show how you balance the charges.

4. Draw the Lewis dot structures for: (Note: make sure it satisfies the octet rule)

  • a. NI3
  • b. CS2
  • c. N2F2
  • d. CH2Cl2

5. a. Which bond is more polar, H–Cl or H–O?
b. Which of the following bonds is the most polar, that is, has the greatest ionic character: H–Br, N–H, N–O, P–Cl?

6. Write the formulas and names for the compounds of the following ions:
F– O2– P3–
K+Ga3+

7. Which families or groups are likely to form the following ions?

  • a. +1
  • b. –1
  • c. +2
  • d. –2
  • e. +3
  • f. –3

8. Draw the following compounds by representing them as covalent bonds using VSEPR Theory:

  • a. CO2
  • b. H2SO4
  • c. CH3OH
  • d. N2O3

9. Show the dipole moment of each bond and then predict the overall molecule as either being polar or nonpolar?

  • a. CH4
  • b. H2S
  • c. PH3
  • d. SO3

How many bond pairs and lone pairs in CH3 Cl?

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Drawing Lewis dot structure

How many bond pairs and lone pairs in CH3 Cl?

What are organometallic compounds? What are current organometallic compounds approved by the FDA for treating cancer? Why are ferrocene derivatives or analogs needed? What advantages would these ferrocene molecules present to the metal-based drugs?

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Week 9 — Literature Search Questions (Virtual Session)

Main Goals

  1. Establish proper literature search to explore ferrocene compounds and their usage.
  2. Provide a list of associated socioeconomic and safety regulations.
  3. Design potential instrumental approaches for the chemical analyses of ferrocene analogies.

Ferrocene Questionnaire
To get a pass for this activity, students’ groups will be required to discuss their findings when asked at the end of the session. It is common to regroup students for 30 minutes and request from them to demonstrate their findings and the resources they utilized. (No notebook pages are required as the OneNote is used, and a record of the work is saved.)

1. What are organometallic compounds?

2. What are current organometallic compounds approved by the FDA for treating cancer?

3. Why are ferrocene derivatives or analogs needed?

4. What advantages would these ferrocene molecules present to the metal-based drugs?

5. Why are we focusing on the investigation of well-known ferrocene standards in this research project?

6. What technique(s) do you recommend for investigating solubility of ferrocene analogs? What results do you expect to see?

7. What technique(s) do you recommend for investigating the purity of ferrocene analogs? What results do you expect to see?

8. What technique(s) do you recommend for investigating the structure of the ferrocene analogs? What results do you expect to see?

9. In what ways do ferrocene compounds have socioeconomic relevance?

10. Share a list of your literature sources.

Using robust details and ample evidence, create a reflective essay that describes 4 learning objectives you met while performing this experiment.

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Chemistry Question

Using robust details and ample evidence, create a reflective essay that describes 4 learning objectives you met while performing this experiment. View the learning objectives from the lab manual provided and select four to focus your writing on.

Calculate the total amount of energy required to convert 35g of ice at -14 to steam at 125 C.

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Chemistry question

Calculate the total amount of energy required to convert 35g of ice at -14 to steam at 125 C.

Demonstrate a detailed understanding of the nucleophilic addition reaction. Provide an overview and examples of nucleophilic addition to a carbonyl group. Draw correctly the mechanism for common nucleophilic addition reactions.

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Chemistry Question

● Demonstrate a detailed understanding of the nucleophilic addition reaction.
● Provide an overview and examples of nucleophilic addition to a carbonyl group.
● Draw correctly the mechanism for common nucleophilic addition reactions.
● Demonstrate a detailed understanding of the Grignard reaction.
● Describe the role of each reagent in the Grignard reaction.
● Explain the sensitivity of Grignard reaction conditions and be able to make procedural adjustments.
● Gain understanding and practical experience of essential laboratory techniques.

Provide the molecular diagrams for the following molecules/ions. Indicate their bond orders HOMO and LUMO and magnetism (diamagnetic/paramagnetic). B2 Cr NO NO* NO-

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Inorganic chem

Provide the molecular diagrams for the following molecules/ions. Indicate their bond orders HOMO and LUMO and magnetism (diamagnetic/paramagnetic).
B2  Cr   NO  NO*   NO-

Calculate the total amount of energy required to convert 35g of ice at -14 to steam at 125 C.

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Chemistry question

Calculate the total amount of energy required to convert 35g of ice at -14 to steam at 125 C.