All things considered, flights havenumerous pros that people can enjoy though they also have some cons which people must work hard to avoid. Do you think that peoplecan overcome these problems by 2025?

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Flight article

“Remember, you fly an airplane with your head, not your hands and feet.” Flights are common these days especially among travellers though they have lots of advantages and disadvantages.

On the one hand, Flights are sometimes advantageous. In the first place, they are considered the fastest means of transportation. They also enable you to travel to any country without being affected by any physical barrier.

On the other hand, flights also have some cons that result in some fatal problems like to global warming. These harmful emissions from planes affect the environment and people badly.

Last but not least, any problem must have some solutions.Firstly, we can invent new planes that produce less emissions, use fuel economically, or use bio fuel that is available and less harmful. This, of course, leads to and better environment for any living creature.

All things considered, flights havenumerous pros that people can enjoy though they also have some cons which people must work hard to avoid. Do you think that peoplecan overcome these problems by 2025?

Create a process and strategy that the operator can follow that will allow for a safe method for each bulleted tasks. Ensure the processes and strategy includes all lifting and bending motions that are required when changing the flat tire.

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Industrial Ergonomics

Answer 3 questions

Question 1

You have sustained a flat tire while driving your company vehicle. The vehicle has a spare tire. In this essay, describe the steps necessary to change out the tire. Focus on the following movements:

  • jacking up the vehicle,
  • removing the lug nuts,
  • lifting the flat tire off the axle,
  • bending over and lifting the spare tire out of the trunk,
  • placing the spare tire on the car,
  • tightening the lug nuts, and
  • placing the flat tire in the trunk.

What specific movements would be required to perform these tasks. Use the textbook Appendix B Physical Risk Factor checklist to explain your answers. Also, discuss the possible work-related musculoskeletal disorders (WMSDs) that could occur.
Create a process and strategy that the operator can follow that will allow for a safe method for each bulleted tasks. Ensure the processes and strategy includes all lifting and bending motions that are required when changing the flat tire.

Your written response answer must be at least 300 words in length.
Question 2

Points Health care workers are at a high risk for WMSDs. Discuss in this essay some of the items that increase their risk of WMSDs. Then discuss how they could alleviate those risks through preventive actions and the hierarchy of controls.

Your response must be at least 200 words in length.
Question 3

PointsConsider an employee who works at the big-box store stocking shelves overnight while the store is closed. The employee begins to experience some mild to moderate low-back pain from the lifting of the boxes. The boxes vary in size and weight. Use the calculations found in Chapter 14 to determine the RWL and LI for this employee. The average weight of the boxes is 40 lbs and the average size is a standard banker’s box. What recommendations could be made based on the findings of your calculations? Show the calculations.

Your response must be at least 200 words in length.

Construct a volcano plot to visualise the changes in fold change and p values from health to sepsis. (By excel) If you assume p<0.05 is significant and prioritise two-fold increased or decreased: name the two most increased and two most decreased proteins of significant interest. What are the biological processes for these proteins?

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Biochemistry Question

Omics_Microbes:

 Introduction

Sepsis (also known as blood poisoning) is the immune system’s overreaction to an infection. Normally the human immune system fights infection but sometimes it attacks our body’s own organs and tissues. If not treated immediately, sepsis can result in organ failure and death. Yet with early diagnosis, it can be treated with antibiotics. Five people die each hour in the UK as a result of sepsis.

Study Design

Blood plasma samples were collected, processed and frozen from subjects visiting the X Hospital Accident and Emergency Unit and who were diagnosed with sepsis. Age and gender-matched control subjects were recruited from the same Accident and Emergency Unit and blood plasma was also collected, processed and stored; these control subjects were tested for but were not diagnosed with sepsis. The sepsis and control samples have been analysed applying a quantitative proteomics method; a specific protein has received a more in-depth mass spectrometry analysis; and the sepsis and control samples have been analysed applying an untargeted metabolomics method to identify changes in metabolites.

Assessment

This assessment will allow you to investigate the data acquired. The assessment is broken down in to three separate sections.

The assessment should be submitted as a short scientific report defining (a) the computational methods applied; (b) the data analysis results generated and (c) a discussion/conclusion section. The maximum word count is 800 words.

 

The data collected is presented in the file named ‘Proteomics data.xls’.

  1. Construct a volcano plot to visualise the changes in fold change and p values from health to sepsis. (By excel)
  2. If you assume p<0.05 is significant and prioritise two-fold increased or decreased: name the two most increased and two most decreased proteins of significant interest.
  3. What are the biological processes for these proteins?

 

Serum samples were extracted and analysed for 15 subjects diagnosed with sepsis and 15 subjects not diagnosed with sepsis. Plasma was extracted in 50/50 methanol/water (v/v). Each sample was analysed applying a ultra-performance liquid chromatography-mass spectrometry (LC-MS) method followed by raw data processing. Quality Control (QC) samples were also analysed as part of the study.

The processed LC-MS data is presented in the file named ‘Omics_Microbes_Metabolomics_dataset_Case_Study.csv’.

  1. Assess the quality of the data provided applying multivariate analysis methods. Define whether the data is of an adequate quality to perform statistical analysis.
  2. Applying univariate statistical analysis methods, identify the metabolites which show a statistical significance between subjects with sepsis and subjects without sepsis. Report the metabolite and statistical critical p-value for all metabolites with a critical p-value < 0.05 (FDR-corrected).
  3. Identify the metabolite pathway or pathways that are associated with the statistically significant metabolites described in part b.

 

Determine if the suspect stole this virtual technology and if so where were you able to find it and what was on the device.

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Hacktivision

Scenario Description

We have reason to believe that the suspect has stolen a sensitive piece of virtual technology from CyberX. This virtual technology belonged to a group of OSINT professionals who worked for CyberX and the suspect was a part of there team. From what we were told this virtual technology was used to replicate a mobile device but that was the extent of what they could share. Your job is to determine if the suspect stole this virtual technology and if so where were you able to find it and what was on the device. Best of luck and lets hope we can find what has been stolen.

Based on the information provided below and discussed in class, prepare a 3 – 4 page report outlining recommendations for preparation and maintenance of an Investigational New Drug (IND) application.

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RGA 6101 – Therapeutic Product Development Spring 2023 Quarter

Assignment:
Based on the information provided below and discussed in class, prepare a 3 – 4 page report outlining recommendations for preparation and maintenance of an Investigational New Drug (IND) application.

Background Information:
Submission of an initial IND and ongoing IND maintenance, perhaps more so than most activities in drug development, require a high level of teamwork and collaboration. IND preparation is a prime example of how a diverse range of skill sets and expertise is necessary in drug development, as its contents include clinical, nonclinical, manufacturing, and administrative sections.
The IND allows a Sponsor to initiate and conduct clinical studies of investigational drugs in the United States. It allows a pharmaceutical company to negate a federal law set forth in the Federal Food, Drug, and Cosmetic Act, and ship an unapproved drug across state lines for clinical trials. Importantly, the IND should provide FDA the data necessary to decide if a new drug and clinical trial pose a reasonable risk to clinical trial participants. Getafix Pharmaceuticals is a small pharmaceutical company developing a compound it hopes to market someday for treating Alzheimer’s disease. With nonclinical studies completed, planned, and ongoing, GMP–compliant manufacturing underway, and a phase I clinical study protocol drafted, it is planning to submit an initial IND submission to FDA for its lead compound within a year. With limited resources and expertise, the company has requested your help as a Regulatory Affairs Consultant.

Prompt:
Outline operational and strategic considerations Getafix should take into account when preparing to submit its initial IND to the FDA. Within your plan, provide a brief introduction describing the indication and currently available treatment. Indicate whether you would recommend a Pre–IND meeting with FDA, and if so, describe the contents of required meeting material and potential goals of the meeting. Describe documentation required for initial IND submission and ensure Getafix understands the necessity of IND maintenance throughout drug development. Justify your recommendations by referencing applicable regulations from 21 CFR and advice from FDA Guidances and ICH Guidelines.

As the course proceeds, reflect on how what you learn in each class could be incorporated into a strategic regulatory plan that helps to guide a pharmaceutical company through various aspects of the drug development process.

Using additional style sheets for tablet and mobile, make the layout created for the assignment responsive.

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Website responsive

Using additional style sheets for tablet and mobile, make the layout created for the assignment responsive.

Consider things like:

  1. shifting the number of columns
  2. size of elements (such as text, images, and buttons)
  3. layout of navigation to be best suited for the various browser widths.

What is the linear regression equation produced by your model? Evaluate. the quality of the model. What is the .12 value? Which. independent variables are significant?

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Climate Change

There have been many studies documenting that the average global temperature has been increasing over the last century. The consequence; of a continued rise in global temperature will be dire. Rising sea levels and an increased frequency of extreme weather events will affect billions of people. In this problem. we 11 study the relationship between average global temperature and several other factors. The file ClimateChange.csv, which is available in the Online Companion, contains climate data from May 1983 to December 2008. The variables are described in Table 22.2.

a) Start by splitting the dataset into a training set, consisting of observations up to and including 2006, and a testing set, consisting of observations after 2006. You will use the training set to build your model, and the testing set to evaluate the predictive ability of your model. Then, build a linear regression model to predict Temp, using all of the other variables as independent variables (except Year and Month). You should use the training set that you just created to build the model.

  • i) What is the linear regression equation produced by your model?
  • ii) Evaluate. the quality of the model. What is the .12 value? (Note that this is called ‘Multiple R-squared” in some software output,) Which. independent variables are significant?

Create a 4- to 5-page BCC Enterprise Information Security Organizational Budget in Microsoft® Word or Microsoft® Excel® that includes at least three of the identified information security initiatives.

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Information Security Budget

Assignment Content

This week you will use information from the previous weeks to complete the BCC Information Security Budget. The chief information security officer (CISO) is tasked with developing a budget to reduce costs and security risks.

Part 1

Create a 4- to 5-page BCC Enterprise Information Security Organizational Budget in Microsoft® Word or Microsoft® Excel® that includes at least three of the identified information security initiatives. The BCC Enterprise Information Security Budget must include the following:

  • Description of the BCC information security department
  • Current situation
  • Personnel
  • Operational situation
  • Operating budget
  • Future requirements

Summary of the information security initiatives planned for implementation, including any additional hardware/software purchases (including financial management tools), personnel, and training requirements

Estimated schedule for the planned implementation of information security objectives

Estimated annual operating budget for the next five years

Part 2

Create a 7- to 9-slide Microsoft® PowerPoint® presentation on a budget plan for an intrusion prevention system (IPS). The purpose of the budget plan is to provide a recommendation to senior leadership on the costs associated with implementing the IPS software. The IPS budget plan should include the following:

  • Title slide
  • Summary of the initiative and product
  • Cost-benefit analysis (CBA)
  • Total cost of ownership (TCO)
  • Return on investment (ROI)
  • Solution alternatives (if any)
  • Recommendation

Explain how a contemporary influence makes either a positive or a negative contribution to peer influence on adolescent sexual decision making. Analyze risk factors associated with the contemporary influences you have chosen.

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SEXUAL DECISION MAKING

Adolescent sexual decision making is a very complex phenomenon. It is a time when individuals may become interested in more intimate relationships and experimentation. During this stage, adolescents may contemplate whether to engage in intercourse or abstain from sexual relations. Many factors may influence an adolescent’s sexual decision making including biological, social, cultural, familial, and experiential factors. Making good decisions and responsible choices about sexual activity during adolescence can have immediate and lasting implications on an individual’s overall health outcomes. For this reason, it is important for social workers to possess an understanding of the context of decision making and social influences as well as educate adolescents on appropriate support programs available to them.

For this Discussion, you explore the contemporary influences on adolescent sexual decision making.

LEARNING RESOURCES

Required Readings

To prepare: Find one example of an influence on adolescent sexual decision making in contemporary society that is directed at adolescent audiences. Examples may include websites, magazines, music, film, television, or advertising.

Post:

  • Explain how a contemporary influence makes either a positive or a negative contribution to peer influence on adolescent sexual decision making.
  • Analyze risk factors associated with the contemporary influences you have chosen.

Develop interdisciplinary research skills and familiarity with feminist theories and modes of inquiry. Describe women’s historical and contemporary contributions to culture and society.

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DEPARTMENT OF WOMEN’S AND GENDER STUDIES: Women & Hip Hop 

At the conclusion of the semester students will be able to
1. Develop interdisciplinary research skills and familiarity with feminist theories and modes of inquiry.
2. Describe women’s historical and contemporary contributions to culture and society.
3. Demonstrate oral communication, writing, and critical thinking skills.
4. Apply what is learned in the classroom into own spoken word/hip hop piece/production and own lives.

PART 1: Research Paper
1) Students will research a female hip–hop or spoken word artist (local, national or global) from 1960–present day [See link https://www.ranker.com/list/female–rappers/whatevayoulike]. You will explore how she campaigned social change. What issue(s) did she address? How effective has she been? What is her impact on bringing wreck? Explore the impact and intersection of gender, race and sexuality on her message. This is NOT a biography cut & paste project.
• Select a Female Hip Hop/Spoken Word Artist– She must have at least 12–15published/performed pieces that follow the criteria for the genre.
• Select a social issue she addresses in her lyrics.
• Annotate the lyrics using course material Joan Morgan, Gwendolyn Pough
• Use gender theory such as (black) feminism, and intersectionality, critical gender theory, African Critical Race Theory, Queer Theory, New–Colonialism to analyze the lyrics. Issues to Keep in the forefront of your critical analysis

2) Write a 9–11 page (typed, 12 size font, proper margin spacing, double–spaced) to introduce your project. You are required to use all textbooks are primary sources and 6 additional sources. Paper should include:

Background of the Problem “She” confronted– History, causal factors (e.g. racism, abuse, patriarchy, power, capitalism, etc.) What where reasons for tackling the issue? What were some of her obstacles? What are her successes? What could she do differently?

Large Gender Issues For project/Paper tied to Hip Hop: Feminist; Public sphere vs. Black public sphere vs. subaltern counterpublic; Capitalism; Queering

Heteronormativity; Patriarchy; Colonialism/Colonialization; Hegemony; Narrative; Standpoint theory; Subjugated knowledge; Politics Representation; Politics of Respectability; Sexism; Racism; Ethic of Love vs. Ethic of Domination; Power; Empowerment

  • a. Utilize a theoretical perspective to analyze the issue.
  • b. Bibliography (APA, Chicago Style, or MLA format)
  • c. Citations required (footnotes or parenthetical notation
  • d. Grammar is critical.