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What stereotypes were invoked in this case and by whom? How did stereotyping influence and or frame the situation for Elsa?

This Case Study Analysis should be 3 pages long with a cover sheet and reference page (cover sheet and reference page do not count in the page minimum).
This is an academic case study. Use correct APA formatting including citing references in the body of your text.
General formatting instructions are below. Items bolded should be included as headings in your paper.

▪ Introduction
Provide an overview of the case (1-2 paragraphs)

▪ Main body
Use the Discussion Questions at the end of the Case Study to guide you. This should be written as a narrative do not directly answer the questions in a Q&A format. Include in your analysis material covered in the textbook, supplemental material is a plus. Consider, assess, and clearly state at least three (3) points that defend your opinion. Identify and acknowledge positives and negatives of your position. Include supporting evidence from your sources, make sure to use proper APA in-text citations when warranted (3-5 paragraphs).

▪ Conclusion
Summarize main findings. Identify and justify the position you have taken (2-4 paragraphs).

▪ References
A list of sources referred to in correct APA format.

Case written by Deanna Malatesta, Associate Professor, O’Neill School of Public and Environmental Affairs, Indiana University

Elsa sat in the parking lot of an upscale condominium waiting for her friend to join her. Elsa’s friend did not drive, so each week Elsa waited in the same parking lot for her friend so that they could go shopping. On this particular day, Elsa noticed a man and two well-groomed children walking to a silver SUV, just a few spots away. The children quietly climbed into the vehicle; the man slid behind the wheel and they slowly drove off. Elsa thought she had seen the children at the condominium before, but she was sure that she hadn’t seen the man and thought he looked out of place. Elsa had an uneasy feeling.

The driver appeared to be between 20 and 30 years of age and Black. One of the younger children appeared to be about three or four years of age, and the other about seven. Both children were Caucasian. Elsa contemplated calling the police to report what she thought looked suspicious but did not want to have her friend come out only to see she had left. After pondering a minute, she decided her friend would have to wait—she could explain it all later.

Elsa exited the lot and caught up to the silver SUV just as it was turning out of the complex. Elsa decided to follow the car, which now was on the highway. As she followed the car, Elsa called 911 and explained the situation. “I am following a man and two children in a silver SUV, and the man looks very suspicious. I have a bad feeling about this. I don’t think he belongs with the children.” Elsa also told the police dispatcher, “it may be nothing, but I would feel just horrible if something happened to these children and I did not report it.” She gave the dispatcher a description of the vehicle, the vehicle license plate number, and her location.

Elsa continued to follow the SUV down the highway. About five more minutes into the drive, she witnessed a police car behind her. The police car pulled in front of her, put its siren on and motioned the silver SUV to pull over. Elsa also pulled over about 50 yards away, far enough not to interfere but close enough to be available in case the police needed to question her.

The officer exited the police car and approached the driver of the silver SUV. “Let me see your identification, registration, and insurance card please.” When the driver asked the officer why he was pulled over, the officer asked, “What is your name and where are you going with these children”? The driver responded. “My name is Steve Clark. I am their babysitter; I am taking them to my apartment to watch them until their mom comes home from work.” The officer asked, “Do you have the mother’s phone number”? Steve looked the number up on his cell phone and gave it to the officer. “Stay in the car and I will be back with you in a moment,” the officer said. Steve and the children waited in the car for about 15 minutes while the officer communicated on the radio with his station. Then another police car arrived. At this point the two police officers had a conversation between themselves. This went on for another 15 or 20 minutes before the first police officer approached Steve once again. With no explanation, the police officer handed Steve back his papers and told him he could leave. Steve asked once again, “Why was I pulled over?” The officer responded, “A woman called 911 and reported that she thought you looked suspicious. I am sorry for the inconvenience. You can go on your way, sir.” By this point Steve just wanted to leave. He was nervous and the kids were very unsettled. The younger child was crying. Steve pulled back on to the highway and went on his way.

To better understand the case, students can take an explicit bias test in about 10 minutes at Harvard’s Project Implicit Bias. In taking the test you will experience the phenomenon yourself. You can choose from many implicit bias types; gender, age, and race are just a few of the options. To receive credit for the test, please take a screen shot of the last page, without the score. This is easily posted on Canvas. The test is available at https://implicit.harvard.edu/implicit/.

Questions

1. Do you think that Elsa thought of herself as a racist?
2. Do you think what happened to Steve would have happened if Steve had been white?
3. What stereotypes were invoked in this case and by whom?
4. How did stereotyping influence and or frame the situation for Elsa?
5. How did stereotyping influence and or frame the situation for the police?
6. What is your opinion about Elsa’s reaction to seeing Steve and the two children?
7. Would training on implicit bias have a beneficial impact? For whom?

8. According to the New York Times best-seller by Cathy O’Neill (2016), “Weapons of math destruction: How big data increases inequality and threatens democracy” using “big data” and some mathematical models can threaten the very fabric of democracy. How might implicit bias be a problem in using big data to make “democratic” decisions? Please give examples cite sources from peer-reviewed journal(s).

References and Additional Resources

Mahzarin, R. Banaji, and Anthony G. Greenwald. Blind Spot: Hidden Biases of Good People Delacorte Press, 2013.

O’Neil, Cathy. Weapons of math destruction: How big data increases inequality and threatens democracy. Crown, New York: Broadway Books 2016.

Payne, Keith, Laura Niemi, and John Doris. “How to Think about Implicit Bias. Amidst a Controversy, It’s Important to Remember That Implicit Bias Is Real—and It Matters.” March 2018. Available at https://www.scientificamerican.com/article/how-to-think-about-implicit-bias/

Select the traditional Hispanic meal “torta tres leches” and write the directions and steps.  This is your own cooking channel on YouTube! You will complete a written assignment About your dish.

It’s time to show off what you know, and cook up a special meal. To incorporate the Spanish vocabulary and grammar you know, you will need to select the traditional Hispanic meal “torta tres leches” and write the directions and steps.  This is your own cooking channel on YouTube! You will complete a written assignment About your dish. Remember your sentences must correspond to the pictures/slides you share of the steps required to execute your recipe. Remember to be creative with the choice of Spanish vocab. Remember to watch your grammar and tense in your sentences. IMPORTANT to Remember that a sentence must have at least have a subject and verb. Remember to properly conjugate your verb and that subjects and verbs must agree. Finally, it must be completely done in COMPLETE sentences in SPANISH. Accent marks, tildes, and any upside down question marks or exclamation points also count towards my score. Pictures need to be included on each slide! THESE DETAILS ARE VERY IMPORTANT!

Describe steps that should be followed to ensure that potential ethical issues are addressed properly as treatment options are determined and applied.

Ethical Issues

Evaluate potential ethical issues that should be considered or guarded against when developing treatment interventions for children   or adolescents.

Describe steps that should be followed to ensure that potential ethical issues are addressed properly as treatment options are determined and applied.

Evaluating Potential Partnerships
As globalization has become increasingly common, so has the importance of analyzing opportunities to create value through outsourcing the supply chain. In this assignment, you will create a checklist to help determine which country might be the best location for parts of your organization’s supply chain.
Scenario

You are a consultant who specializes in helping U.S.-based businesses expand into new international locations. You have a new client who’s looking to outsource their company’s manufacturing of hard drives and computer memory, and it’s your job to assist in selecting the new locations. The company is very focused on quality, sustainability, and equality, and your client would like these attributes upheld in the new manufacturing locations.

Your task is to evaluate two of the following countries:

India
Mexico
Thailand

Then, recommend one country you believe would be the most suitable for the company’s new manufacturing facility, and one country that would be considered the least suitable.
Prompt

Evaluate both countries being considered for a new manufacturing facility through exploration of course and outside resources. Then, recommend the most and least suitable location based on the company’s attributes and requirements.

Specifically, you must address the following rubric criteria:

Sustainability Measures and Environmental Regulation: Briefly describe sustainability measures and regulations in each country, and analyze how they may work well with or create conflict or tension with your U.S.-based company.
Examples of items to consider include regulations around pollution, waster, and power sources.
Cost and Workforce: Briefly describe each country’s workforce for the creation of computer components and the cost of that labor.
Examples of items to consider include workforce education levels, the overall cost of labor, types of manufacturing available in the country, and the existence of a specialized workforce that can create computer components.
Government Regulation: Briefly describe the overall regulatory environment of each country. Take the most likely mode of entry into consideration for each country.
Examples of items to consider include the types of manufacturing operations allowed in the country, the labor regulations, and the overall business regulations.
Intellectual Property: Briefly describe the risk of intellectual property being stolen by creating a manufacturing location in each country.
Examples of items to consider include each country’s reputation when it comes to intellectual property, intellectual property regulations, and any other legal protections for intellectual property.
Reputation: Briefly describe the ways an organization can face reputational risk through outsourcing its manufacturing to each country.
Examples of items to consider include if and why other organizations have closed manufacturing locations in each country, how your organization’s customer base will view manufacturing in each country, and the protections each country provides to its workforce and the environment.
Recommendations: Based on your evaluations of the key attributes and requirements, recommend one country that is the most suitable location for your client’s new manufacturing facility, and one country that would be the least suitable location. Justify your recommendations with evidence from your evaluations and the course resources.

Guidelines for Submission

Submit this assignment as a 500- to 750-word Word document. Sources should be cited according to APA style.

Write a 5-page (double-spaced) essay, comparing and contrasting the feminist ideologies explored in Angela Davis’s “I Used to Be Your Sweet Mama” and those described in one other text from the syllabus (Hurston, Collins, Duncan, Combahee, Griffin, or Lorde). In this paper you must provide analytical readings of the texts. Your paper should identify and define the specific ideologies outlined by each of the authors you discuss, outlining their historical context and significance. Your response should include close analysis of each article, including direct citations to help support your arguments. Be as specific as possible in developing your views and cite particular events, historical moments, scenes, passages, and stylistic effects that support your interpretation (include page numbers in all citations). These essays should be double-spaced, 12-point font, and proof read. Grammatical and spelling mistakes will be penalized.

Here are the 4 things to consider as you put together your draft:

 

1. Choice of evidence (Have you cited relevant passages from the texts under discussion?)
2. Discussion of evidence (Have you engaged in critical analysis of the passages cited?)
3. Organization (Does your argument proceed in a logical manner? Is there a clear explanation for the order in which you have analyzed your evidence?)
4. Thesis (Is there some gesture toward an argument? It’s okay if this is provisional in the draft stage.)

Why are scientists so reluctant to let go of Koch’s postulates even though they often chafe – as Koch did – under their restrictions> Why are Koch’s postulates, with all of their problems, still as relevant today as they were when Koch first proposed them?

The Power of Bacteria

2. More and more research groups are seeking to show that changes in the microbiota of a particular site are involved in diseases such as periodontal disease, inflammatory bowel disease, and premature birth. Critics object that showing an association is not the same as demonstrating cause and effect. In the case of the obesity study, scientists tried to do this by inoculating germfree mice with different variations of the microbiota. Clearly, this would not be possible in humans. How might you prove cause and effect in humans?

4. Members of the microbiota cause some quite serious diseases. How could a bacterium that normally lives in a beneficial or neutral association with its human host cause serious disease?

6. The assertion is made in this chapter that scientists now believe that transfer of DNA by conjugation in the colon is occurring across species and genus lines. Suppose you found the same type of antibiotic-resistance gene in members of two different genera. What criteria might you use to show that the gene was transferred horizontally? How might you suspect that the gene was transferred by conjugation?

8. PCR combined with sequencing can provide a quick identification of bacteria. What are the limitations of this approach?

Reading Review Questions – Chapter 6
The Power of Bacteria

2. Why are scientists so reluctant to let go of Koch’s postulates even though they often chafe – as Koch did – under their restrictions> Why are Koch’s postulates, with all of their problems, still as relevant today as they were when Koch first proposed them?

4. We mentioned the possibility that some diseases might be caused by shifts in the microbiota of a site on the human body. Along these lines, some oral microbiologists have pointed to an association between gingivitis (gum disease), caused by microbes found in dental plaques and cardiovascular disease. Could you formulate Koch’s postulates for such a disease? If so, how would you set up an experiment to satisfy these postulates?

6. Are there certain disease cases where it might be allowable to use human volunteers as experimental subjects in order to satisfy Koch’s postulates? What are those instances?

Solving Problems in Bacterial Pathogenesis
2. You have just received an urgent call from the Centers for Disease Control and Prevention (CDC) to consult on the following case of an unusual disease outbreak that they have been investigating. A new Gram-positive bacterium related to Listeria monocytogenes was isolated from an outbreak of food poisoning in Wisconsin due to contaminated cheese that appears to cause painful gastritis and, in about half of the exposed individuals, sudden onset of bleeding ulcers, followed by death from toxic shock within two to three days. Upon biopsy of the infected individuals, it was found that the bacteria were growing on the surface of epithelial cells lining the gastric pit of the stomach. Autopsy of individuals who died showed that bacteria were found only in the stomach and not in any of the other body organs. The researchers at the CDC have subsequently determined that, like Listeria monocytogenes, this new species of Listeria invades epithelial cells in tissue culture. Which, if any, of Koch’s postulates have been satisfied for the involvement of this new Listeria strain with gastritis, bleeding ulcers, and toxic shock? What additional measures could the researchers take to help satisfy Koch’s postulates?

4. In 1976, the Bellevue-Stratford Hotel in downtown Philadelphia hosted a convention of members of the American Foreign Legion. During the convention, 221 legionnaires developed a new form of pneumonia and 24 people died. Infectious disease specialists working for the CDC were sent to Philadelphia to identify the cause of this new, mysterious illness, which not surprisingly was named Legionnaires’ disease. Using Koch’s postulates, list the steps that those specialists had to take to complete their assignment. Briefly explain the significance of each step. These specialists understood that it is not always possible to follow Koch’s postulates to the letter. As they embarked on their quest to identify the causative agent of this new illness, list at least two problems that they might have faced in attempting to fulfill Koch’s postulates.

 

Give a summary of what this article is explaining and talking about .file:///C:/Users/Aida/Downloads/ElementsofJournalismChapter1WhatisJournalismFor%20(1).pdf

What is Journalism For ? (Article)

Give a summary of what this article is explaining and talking about .file:///C:/Users/Aida/Downloads/ElementsofJournalismChapter1WhatisJournalismFor%20(1).pdf

Respond to this response below. Your intake on this persons response to the article “The History of Mary Prince, A West Indian Slave, Related by Herself” .

Respond to this response below. Your intake on this persons response to the article “The History of Mary Prince, A West Indian Slave, Related by Herself” .

 

“The History of Mary Prince, A West Indian Slave” as related by herself is an intriguing read. It was horrifying to read how many times Prince was handed around as a child whenever her slave owners were unable to keep her, one of those times where she was handed around that stuck out to me was “I had scarcely reached my twelfth year when my mistress became too poor to keep so many of us at home; and she hired me out to Mrs. Pruden, a lady who lived about five miles off, in the adjoining parish, in a large house near the sea. I cried bitterly at parting with my dear mistress and Miss Betsey, and when I kissed my mother and brothers and sisters, I thought my young heart would break, it pained me so. But there was no help; I was forced to go.” (Prince, 4). Prince didn’t have a stable life as a child, and it was unfortunate how she grew up being handed off to different people, even being sold to raise money for a wedding as stated “rs. Pruden came to me and said, “Mary, you will have to go home directly; your master is going to be married, and he means to sell you and two of your sisters to raise money for the wedding.” Hearing this I burst out a crying,–though I was then far from being sensible of the full weight of my misfortune, or of the misery that waited for me” (Prince, 4). Her life was not easy and she was incredibly mistreated on the plantation with her most recent owners either, their treatment was harsh, even while they were in England as well. It was appalling that even while in England the mistress was so cruel to Price, one instance was when her joint pain was flaring up, being cited as “When I complained to my mistress of this, she only got into a passion as usual, and said washing in hot water could not hurt any one;–that I was lazy and insolent, and wanted to be free of my work; but that she would make me do it. I thought her very hard on me, and my heart rose up within me.” (Price, 13). It was appalling treatment that nobody should be subjected to. I found relief though when she finally stood up and left her owners while she was in England, it was very brave of her to finally do that and I was very happy that she was finally getting away from all the abuse. The part that was the most relieving was when she stated “I lived a good many months with these poor people, and they nursed me, and did all that lay in their power to serve me.” (Price, 14). It was good finally seeing Price be treated well, as she did not deserve the mistreatment she had received over the course of her life.
The video, “How Slavery Shaped Our Cities” relates to the reading a bit. Mary Price’s account gives a greater understanding of the video. Price’s account had greatly explained what had happened to her body through the strenuous work and even the horrific abuse, the development of rheumatoid arthritis, and the countless beatings that she had endured at the hands of her slave masters as well as the other treatments the slaves around her had gotten. That coincides with the brutal treatment mentioned briefly in the video. Both also relate to each other with the sale of slaves for profit as mentioned in the video, with Price’s case also being related to her being sold at one point for her owner to get more money for a wedding (Price, 4). The video also mentioned plantation work, which also aligns with Price’s telling of her life. Her work gives an in-depth detailing of how arduous and stressful on the body the plantain work was that the video does not explore, with all the tasks she had undertaken there such as “Picking cotton and wool” (Price, 7). Price’s work gives a greater understanding of the video by providing an in-depth detailing of the treatment that slaves had received at that time, greatly aiding in understanding what the video mentions.

Write a summary on this article and make sure to explain each one of the figures

Write a summary on this article. Given an example. It’s really important that the summary looks like example.Make sure to explain each one of the figures

PRESTO-TANGO: an open-source resource for interrogation of
the druggable human GPCR-omeW.K. Kroeze1, M.F. Sassano1, X.-P. Huang1, K. Lansu1, J.D. McCorvy1, P.M. Giguere1, N. Sciaky1, and B.L. Roth1,2
1Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27514, and National Institute of Mental Health Psychoactive Drug Screening Program1, University of North Carolina, Chapel Hill, NC 275142Program in Neuroscience, University of North Carolina, Chapel Hill, NC 27514, and Division of
Chemical Biology and Medicinal Chemistry2, University of North Carolina, Chapel Hill, NC 27514

Abstract
G protein-coupled receptors (GPCRs) are essential mediators of cellular signaling and important targets of drug action. Of the approximately 350 non-olfactory human GPCRs, more than 100 are
still considered “orphans” as their endogenous ligand(s) remain unknown. Here, we describe a unique open-source resource that provides the capacity to interrogate the druggable human GPCR-
ome via a G protein-independent β-arrestin recruitment assay. We validate this unique platform at more than 120 non-orphan human GPCR targets, demonstrate its utility for discovering new
ligands for orphan human GPCRs, and describe a method (PRESTO-TANGO; Parallel Receptor-ome Expression and Screening via Transcriptional Output – TANGO) for the simultaneous and parallel interrogation of the entire human GPCR-ome.
G protein-coupled receptors (GPCRs) are proteins with seven transmembrane helices capable of transducing a wide variety of extracellular stimuli into intracellular signals, mediated by G proteins of four groups, Gs, Gi, G12 or 13 or Gq, as well as arrestins and other effectors1. The human genome encodes more than 350 different non-olfactory GPCRs, as well as a similar number of olfactory GPCRs24. In addition to their roles as signal
transducers, GPCRs are the targets for more than one-third of currently prescribed medications
5, 6. Approximately one-third of the non-olfactory GPCRs in the human genome
are “orphan” GPCRs, i.e., their endogenous or natural ligands are unknown
24, while many more are inadequately interrogated with respect to their ligands. Thus, much of the
druggable GPCR-ome – like other drug target families such as the kinome
7, represents ‘dark
Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research,
subject always to the full Conditions of use:
http://www.nature.com/authors/editorial_policies/license.html#termsCorresponding author: Bryan L. Roth, 4072 Genetic Medicine, UNC-CH School of Medicine, Chapel Hill, NC 27599-7365; Phone:
919-966-7535; Fax: 919-843-5788; bryan_roth@med.unc.edu.
WKK, MFS and X-P H: Contributed equally
AUTHOR CONTRIBUTIONS: BLR and WKK conceived the general approach; WKK designed the constructs; WKK, FS, KL and
XPH executed and analyzed validation, profiling and confirmatory assays; JDM and PMG validated assays; NS assisted with high
content microscopy; FS designed, executed and analyzed the simultaneous profiling strategy; BLR, WKK, FS, KL and XPH wrote the paper; BLR was responsible for the overall strategy.

HHS Public AccessAuthor manuscriptNat Struct Mol Biol. Author manuscript; available in PMC 2015 November 01.
Published in final edited form as:
Nat Struct Mol Biol. 2015 May ; 22(5): 362–369. doi:10.1038/nsmb.3014.

Author Manuscript Author Manuscript Author Manuscript Author Manuscript
matter’ of the human genome. As many of these sparsely annotated GPCRs will likely represent fruitful future therapeutic targets, identifying drug-like chemical leads for the
entire family of druggable GPCRs represents a major goal for chemical biology.
Unfortunately, interrogating the druggable GPCR-ome en masse in a parallel and simultaneous fashion is currently technologically and economically unfeasible.
The difficulty in screening the entire druggable GPCR-ome in parallel is due mainly to the
inherent diversity of signal transduction cascades, rendering attempts at parallel profiling challenging. Thus, for instance, functional assays for the identification of agonists at orphan
and other sparsely annotated GPCRs have typically used readouts that depend on the native or forced
1 coupling of GPCRs with G proteins, e.g., Gs, Gi, Gq or G12 or 13814.
Unfortunately, these approaches are not well suited for the parallel and simultaneous genome-wide interrogation of the druggable GPCR-ome
1. Alternatively, measurement of G-protein independent β-arrestin recruitment provides a feasible and universal assay platform, since nearly all tested GPCRs can induce arrestin translocation15, 16 (Supplementary Table
1). A wide variety of approaches has been described to quantify GPCR-β-arrestin interactions, including high content screening (HCS)
17, bioluminescence resonance energy transfer (BRET)18, enzyme complementation19, and transcriptional activation following arrestin translocation (TANGO)20, although none are routinely performed in a genome-wide, parallel manner. As we show here, the TANGO approach has a number of advantages for high throughput assays, including its independence from G protein coupling, generally high signal-to-background ratios, and its amplification of relatively small initial inputs into large readout signals. Independence from G protein coupling facilitates interrogation of orphan GPCRs, whose coupling partners are unknown. Some of the advantages of the TANGO assay might also be shared by other readout systems, including, for example,
assays for changes in impedance or dynamic mass redistribution (reviewed in
21) and indeed, arrestin recruitment may be part of the dynamic mass redistribution response measured in receptor-expressing cells responding to agonists, as suggested, but not directly shown, by the results of Hennen et al22. Our goal was to develop the TANGO assay into a platform that could encompass the entire druggable GPCR-ome. Although our assay does not differ significantly in terms of the general concept from that of Barnea et al.20, several notable changes including the design of the plasmid constructs and assay execution have
distinct advantages, as we describe below. We also demonstrate a method (PRESTO-TANGO; Parallel Receptor-ome Expression and Screening via Transcriptional Output-TANGO) that facilitates the rapid, efficacious, parallel, and simultaneous profiling of
biologically active compounds across essentially the entire human druggable GPCR-ome.
Additionally, we document how our approach leads to the facile identification of new
synthetic and naturally-occurring agonists for orphan GPCRs. Finally, as our platform is open-source, our methods and reagents are made freely available to the scientific community.

Kroeze et al. Page 2

Nat Struct Mol Biol. Author manuscript; available in PMC 2015 November 01.

Author Manuscript Author Manuscript Author Manuscript Author Manuscript

 

Below is the general format you should use for your reviews. You should add more details for each section, this is just an example for format.

Baird et al. – 2014 – HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span
Discovered that thermotolerance is regulated by HSF-1 but not through upregulation of heat shock proteins as previously thought.
They authors used molecular biology techniques such as PCR, plasmid construction methods, etc. to show that truncated versions of the HSF-1 gene have decreased transcriptional activity in C. elegans.
Fig 1. Only the full-length HSF-1 gene leads to heat shock protein expression, however both full length and truncated genes increase thermotolerance and life span.
Fig 2. HSF-1 regulates PAT-10 expression. Knock out of PAT-10 causes a decrease in thermotolerance and overexpression increases thermotolerance. The PAT-10 effect is independent of heat shock proteins.
Fig 3. Use fluorescence microscopy and GFP to assess the actin cytoskeleton. Loss of PAT-10 leads to a messed-up actin cytoskeleton when animals were heat stressed. Overexpression of PAT-10 protected the actin cytoskeleton from heat stress. Overexpression also delayed the decrease in F actin that is normally seen with aging.
Fig 4. Using pharmacology they showed that disrupting the actin cytoskeleton in human cells also impaired their thermotolerance.
The transcription factor HSF-1 affects thermotolerance by controlling the expression of PAT-10, which is required to keep the actin cytoskeleton from collapsing. HSF-1 regulation of PAT-10 is independent of its heat shock protein responsibilities. Over-expressing PAT-10 increased thermotolerance and life span. Pathways that activate PAT-10 should be explored further because the pathway would make a good target for the treatment of age-related diseases.

Discuss how the strategy for key stakeholders may improve population health outcomes. Be sure to explain your reasoning. Summarize your analysis and recommendations in a brief concluding paragraph.

IHP 610 Final Project Issue Prompt Option #2: Immunizations

 

The Health Law and Policy Issue: The State of Evergreen adopted comprehensive immunization legislation 60 years ago. The legislation addresses compulsory immunization requirements for children attending public school and for healthcare workers. The language mandating compulsory immunizations for children makes available two exemptions: one for firmly held religious beliefs and the other for medical safety reasons. The only exemption available for healthcare workers is the exemption for medical safety reasons. The legislation has remained largely intact and without modification since it was passed. Three major counties in the State of EvergreenCedar, Fir, and Pineexperienced large whooping cough outbreaks during the past year. Two children and one adult died in the outbreaks. It is unclear whether any of the three had been vaccinated against whooping cough. In the past 10 years, Pine
County experienced a measles outbreak and several particularly bad flu seasons. Cedar County and Fir
County experienced occasional measles outbreaks.
In response to the outbreaks, the Evergreen Legislature is considering legislation to remove the exemption for firmly held religious beliefs. If the legislation passes, public schools will continue to be
responsible for enforcing the immunization requirements.
The Tourism Bureau in Evergreen looked at statistics for the last 10 years and concluded that tourism to the state was negatively impacted by the outbreaks. As a result, the business community largely supports the proposed legislation. Elected representatives from Cedar County and Fir County oppose the bill. Several large congregations in those counties oppose vaccinations on religious grounds.
Representatives from Cedar and Fir Counties have sponsored a bill to add a third exemption to the existing immunization legislation. That provision would allow parents to exempt their children from
vaccination if they have a “personal objection” to the vaccine or vaccines.
School nurses in all three counties are concerned about public backlash if the religious exemption is removed from the law. School administrators are worried that they will not have the funds and staff power to enforce the more restrictive immunization requirements. Funding is lean as it is. The state association of school administrators has argued in the past that it is difficult to enforce the immunization requirements. It is hard to ban a child from school if he or she is not sick. The primary care association in Evergreen was asked to provide comment on the proposed legislation.
While the association refused to comment on the legislation, the association offered the following statements for consideration:

It is expensive to purchase and maintain a supply of vaccines in a primary care office.

Many primary care offices (including pediatric practices) are choosing not to administer vaccinations.

The practices send their patients to public health departments for vaccinations.

Public health departments do not know when a patient has been referred for vaccinations.
There is no regional health information exchange or shared electronic medical record system.

Public health departments in Evergreen cannot bill commercial insurance plans for administration of vaccines.


You are a policy aide employed by the State of Evergreen. Your supervisorthe governor’s special
advisor on healthhas asked you to review the proposed legislation, consider all relevant perspectives
and facts, and draft a policy memorandum. Specifically, your memorandum must make a
recommendation regarding whether the governor should support the legislation, oppose the legislation
(and veto it if passed), or take some other action. Be sure your policy memorandum addresses both
pieces of legislation discussed above.

Policy Memorandum: Immunizations
Executive Summary
The State of Evergreen has put it mandatory for public school children to undergo immunizations in the past 60 years, with the exemption being medical safety reasons and firm religious beliefs. Regardless of the requirements in place, in the last year, an adult and two children died in a whooping cough outbreak. At the same time, all counties with the State of Evergreen have seen measles outbreaks, with Pine County experiencing an extremely bad flu season. The need to remove the firm religious beliefs on immunization has seen divided support among different stakeholders such as the business sector, elected officials, healthcare professionals, parents, school administrators, teachers, and religious groups.
The key issue, in this case, is whether the adoption of the religious exemption in the immunization process is justified in the protection of public health. According to Rundall (2016), most states now have some sort of religious exemption when it comes to the topic of immunization. However, there also exist some other difficulties in the adoption of this legislation for mandatory immunizations, and such include there is no central electronic health record system in the primary care offices, thus making it hard to know who needs vaccination. The public health department further lacks an effective insurance plan for the vaccination costs, and the school administrators are concerned about the burden this would add to the enforcement of new guidelines, especially with the current minimal funding. However, looking at the 1905 case of Jacobson vs. Massachusetts, the Supreme Court decided that a State has the authority to enact and enforce laws that protect public health, and this includes mandatory vaccinations.
The Governor ought to abolish the religious exemption to vaccination. The State of Evergreen has suffered public health crises due to upholding individual preferences; thus, the state needs to protect public health.
Factual Overview
Importance
In the prevention of diseases within the United States, immunizations have played a significant role. Preventing communicable diseases outbreaks is vital in the health and safety of the public; thus, taking the necessary precautions is critical (Ventola, 2016). It is for this reason that the State of Evergreen has been at the forefront to change the immunization legislation. The Evergreen legislation is aimed at removing the religious beliefs exemptions and implement mandatory vaccination to all public-school children. As more of the population receives an immunization to a given disease, they become immune to a particular disease, thus leading to its eradication. Outbreaks can lead to economic downturns, and this is evident in the Evergreen State, where businessmen have incurred losses due to these outbreaks. It is for this reason that supporting immunization legislation is crucial to ensure that preventable diseases are eradicated and ensure the safety of the general population (Rodrigues & Plotkin, 2020). However, it is important to note that the removal of the religious beliefs exemption can result in legal disputes and unrest, which can further hamper economic growth.
Stakeholders
The key stakeholders affected by the change of legislation include the school-going children, parents, school nurses, school administrators, healthcare providers, the business community of Evergreen State, and the religious leaders in the communities. The children and parents are the ones who are most affected since the implementation of mandatory immunization will go against the religious beliefs they possess (Randall, 2016). The religious leaders who are also the custodians of these beliefs will feel offended by the legislation which violates the religious beliefs. Nurses, on the other hand, will be afraid of facing backlash from the community on the aiding of the violation of the religious beliefs, while school administrators will be concerned with the increased burden. Lastly, the business community will support the legislation to avert another economic loss like the one they incurred in the past outbreak. It is thus crucial to have a thorough and joint agreement on all the stakeholders affected by the mandatory immunization legislation. Undertaking public education, community engagement, and providing adequate funding for school administrators can help the legislation to be accepted.
Role
Some stakeholders such as the religious entities, children, and parents positively contributed to the formulation of the legislation since they wanted to exercise the constitutional right to religious freedom. By using the religious freedoms to refuse the vaccinations, these stakeholders positively contributed to the past outbreaks that occurred. Therefore, the elected representatives thus viewed the religious exemption as the reason as to why the past outbreaks occurred as well as the business community sees this religious exemption as a threat to the whole population (Randall, 2016). Therefore, as the role of the elected individuals is to protect the whole population and maintain public safety, mandatory vaccinations are thus crucial regardless of religious beliefs.
Legal Risks and Malpractice Issues
The legal risks linked to the legislation are immense due to the outcomes on the different stakeholders. For instance, if the State of Evergreen experiences another outbreak that emanates from the unvaccinated individuals, the business community can sue the state for incurred losses and damages. They can hold the state accountable for failing to prevent another public health crisis. On the other hand, with the passing of the legislation, the parents will have the right to sue because their rights to practice their religious beliefs freely have been infringed. Clinical professionals also can be sued for not respecting patient autonomy as the patients have the right to refuse or accept any form of treatment. Therefore, the healthcare professional forcing to implement the legislation can further be sued for infringing this right. Although the Supreme Court ruled that States have the mandate to use police powers in protecting the health and safety of the public, States can still be sued for infringing religious freedom.
Value Conflicts
The different stakeholders possess their own personal conditions, and each is considered justifiable from the different stakeholders’ points of view. However, what is specified in this scenario is not what is best for an individual stakeholder, but it is the best approach for the collective good of the whole population. For that reason, there are some value conflicts that are more likely to occur between the legislators and the stakeholders who do not want their religious beliefs to be interfered with. Healthcare providers will further experience a value conflict since, as the personnel who are tasked with offering healthcare services, they have the moral obligation to administer care to patients (Tumpey et al., 2016). However, in the case of infringing the individual rights to administer the vaccine, the healthcare professionals may feel conflicted about doing the same. In a nutshell, the decision to get the school children to be immunized or not is not a personal choice as it may seem but one that is well integrated into public health. Therefore, parents, religious leaders, and any other stakeholder opposed to it may feel conflicted as they must conform to the public health requirements regardless of their beliefs.
Immunization Analysis
Needs and Interests
The legislation on immunization has had the stakeholders debating the issue from both ends. While some stakeholders support mandatory vaccinations, some parents and religious organizations are opposing the legislation, and both sides offer a valid argument. The main concern held by those in opposition to the legislation is the infringement of autonomy and their violation of the first amendment, but importantly they are concerned about their safety as the vaccine efficacy is unknown (Rodrigues & Plotkin, 2020). Nevertheless, despite holding these opposing views, referring to the Jacobson vs. Massachusetts 1905 case, individual liberty is not an absolute aspect and is subject to state police powers. This means that despite their opposition, they can be forced to take the vaccine to enhance public safety.
Current Laws, Policies, and Financing
With the vaccination policies in schools being state based, the state of Evergreen has the risk of financial consequences when the vaccination law is implemented. There will be increased insurance premiums that will lead to a possible decrease in the number of children enrolling in public school (Ventola, 2016). The increased risk of illness due to children adopting homeschooling techniques can further result in a negative financial impact on the state. Therefore, it is for the State of Evergreen to adopt a vaccination policy that appropriately meets the different stakeholders’ needs.
Conflicts
The potential value conflict that emanates from this immunization legislation is the possibility of infringing the people’s rights that are well documented in the First Amendment (McKee &Bohannon, 2016). While the State and some business owners are concerned with maintaining public safety some parents, children and religious leader hold their religious beliefs dearly.
Legal Risks and Malpractice Issues
The legal risks linked to the legislation include the legal actions for the state mandating the parents to vaccinate the children against their religious belief or wishes or if the vaccine makes the children become ill. However, according to the Prince vs. Massachusetts 1940 verdict, the government has broad authority on regulating and treatment of children; thus, it is evident that the State of Evergreen has some legal backing in implementing the legislation.
Analysis of Stakeholder Needs and Interests
The State of Evergreen has proposed legislation that seeks to remove vaccine exemptions for special groups that cite religious beliefs. This proposed legislation has amassed support from the business communities since they seek to protect their business from losses as it happened in the last outbreak. However, there is vast opposition from parents, religious leaders and some local government representatives who argue that the residents have the freedom to practice their religious beliefs devoid of government interference (Rodrigues & Plotkin, 2020). Similarly, the debate has created an unfavorable situation for school administrators and staff who are unsure of how to implement the suggested legislation due to limited resources and maintain compliance with the state policies. In the event that this legislation passes, it will affect the different stakeholders in different ways. However, the State of Evergreen will be hit hard with the legislation as it will face the challenge of fully implementing the immunization campaign due to the shortage of resources.
Application of Laws, Policies, and Financing Practices
The State of Evergreen can use the current healthcare laws and policies relevant to the issue at hand to satisfy the different stakeholders. The U.S. Constitution mandates the state to exercise its police powers as far as maintaining public health and safety is concerned. The U.S. Constitution further recognizes the freedom of religion; however, a constitutional requirement for nonmedical exemptions does not exist. Vaccines have further proven to have the possibility of reducing communicable diseases; thus, all stakeholders need to recognize the real-world implications of taking proper precautions (Rodrigues & Plotkin, 2020). Understanding the correlation that exists between vaccination and morbidity rates is further necessary as a means for Evergreen to adopt the immunization policy that protects the public. On the financial constraints that are rampant in public schools, the school administrators ought to seek alternative sources of funding. These alternatives include federal grants such as the Vaccines for Children Program (VFC), which can help to purchase the vaccine and meet other vaccine administration purposes.
Conflicts
The stakeholder value conflicts mostly emanate from individual bias and misinformation on the concept of vaccination. Most of the disagreement of mandatory vaccination stems from the parents and other stakeholders’ limited information on the health benefits of the vaccines (McKee & Bohannon, 2016). On the other hand, religious beliefs tend to be taken out of context, where despite most religions supporting the need for healthy living, some interpret the mandatory vaccination from an out of context, thus generating unnecessary fear. Therefore, there is a need to ensure that necessary education is conducted on the potential benefits of the vaccine to allay any underlying fears among the different stakeholders.
Legal Risks and Malpractice Issues
The State of Evergreen needs to proceed with utmost precaution while debating the issue to avoid any possibility of being sued. Residents can sue the state for the failure to protect their health and safety if the immunization is not carried out and an outbreak occurs (Ventola, 2016). To protect the general public and avoid any potential suit, the State of Evergreen needs to use the Supreme Court case of Jacobson vs. Massachusetts where infringing of the religious freedoms as a means to protect public health does not in any way violate the First Amendment. On the other hand, the current immunization and health record management procedures within Evergreen state are insufficient and not compliant with the electronic health record federal mandate. This exposes the public health department and the primary care physicians to malpractice litigation; hence this needs to be put into consideration.

 

References
McKee, C. &Bohannon, K. (2016). Exploring the reasons behind parental refusal of vaccines.
Journal of Pediatric Pharmacology and Therapeutics, 21(2), 104–109. doi:10.5863/1551-6776-21.2.104
Randall, K. (2016). Kansas, Please Protect Our Children: Why Kansas Should Remove the
Religious Exemption for Mandatory School Vaccinations. Kansas Law Review, 64(5),
1217–1254. https://doi.org/10.17161/1808.25546
Rodrigues, C., & Plotkin, S. A. (2020). Impact of vaccines; health, economic and social perspectives. Frontiers in Microbiology, 11, 1526.
Tumpey, A. J., Daigle, D., & Nowak, G. (2018). Communicating during an outbreak or public health investigation. CDC, Epidemic Intelligence Service. [(accessed on 30 January 2020)].
Ventola, C. L. (2016). Immunization in the United States: recommendations, barriers, and measures to improve compliance: part 1: childhood vaccinations. Pharmacy and Therapeutics, 41(7), 426

Using the attached paper and prompt on Immunizations answer the below questions you can use the sources already listed in the FINAL document if needed.

Recommendations
a. Recommend a course of action to the healthcare executive. The course of action you recommend must be supported by your analysis.
b. Propose how you plan to reconcile divergent stakeholder needs and interests.
c. Assess the extent to which legal risks and potential malpractice issues shaped your decision, if at all. Be sure to explain your reasoning.
d. Assess the extent to which your recommended course of action addresses financing practices that impact key stakeholders, if any. Be sure to
explain your reasoning.
e. Propose how you plan to resolve potential conflicts you identified. Be sure to identify the risk management strategies you would employ.
f. Propose a strategy for key stakeholders to influence the healthcare executive’s decision.
g. Discuss how the strategy for key stakeholders may improve population health outcomes. Be sure to explain your reasoning.
h. Summarize your analysis and recommendations in a brief concluding paragraph.